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Rabies (Latin, rabies, "madness, rage, fury") is a viral zoonotic disease that causes acute encephalitis (inflammation of the brain) in mammals. In non-vaccinated humans, rabies is invariably fatal after neurological symptoms have developed, but prompt post-exposure vaccination may prevent the virus from progressing. Only six humans are known to have survived rabies after the onset of symptoms. There is only one known case of a person surviving rabies without treatment.